{"schemaVersion":"cwiki-fiche-1.0","identifiers":{"inchiKey":"RNOOXKZJDRWUEI-INIZCTEOSA-N","prefName":"5F-MDMB-PINACA (5F-ADB)","symbol":"5F-MDMB-PINACA","iupacName":"methyl (S)-2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate","aliases":["5F-ADB","5F-MDMB-PINACA"],"cas":"1715016-75-3","pubchemCid":"118798967","chebiId":null,"smiles":"CC(C)(C)[C@@H](C(=O)OC)NC(=O)C1=NN(C2=CC=CC=C21)CCCCCF","molecularFormula":"C20H28FN3O3","molecularWeight":377.46,"xrefs":{"pubchem":"https://pubchem.ncbi.nlm.nih.gov/compound/118798967"}},"classification":{"family":"scra","familyLabel":"Cannabinoïde synthétique (SCRA)","origin":"synthetic","originLabel":"Synthétique","structuralClassFr":null},"originSynthesis":{"heading":"Origine (recherche pharmaceutique → marché illicite)","summaryFr":"Indazole-3-carboxamide à tête tert-leucinate méthyl-ester et chaîne 5-fluoropentyl ; vague 3 SCRA","originNote":"Marché illicite (origine académique inconnue)","discovered":"2014"},"pharmacology":{"summaryFr":"5F-MDMB-PINACA (5F-ADB) - indazole-3-carboxamide, tête tert-leucinate méthyl-ester, queue 5-fluoropentyl. Caractérisation par Banister et al. (ACS Chem Neurosci 2016) : EC50 CB1 ≈ 0,59 nM. SCRA le plus fréquemment saisi en Europe 2018-2020 (rapports EUDA). Décision d'exécution (UE) **2018/1485** étend le contrôle. CND **62/8** (mars 2019) place sous Annexe II de la Convention de 1971. France : **Arrêté 31 mars 2017** (NOR AFSP1710288A) - listé Annexe IV avant même la décision UE.","receptorSummaryFr":"Agoniste complet CB1 (EC50 ≈ 0,59 nM β-arrestine) - extrêmement puissant","binding":[{"target":"CB1","efficacy":"full_agonist","relativeActivity":99,"reported":"EC50 ≈ 0,59 nM","confidence":"medium"},{"target":"CB2","efficacy":"full_agonist","relativeActivity":90,"reported":null,"confidence":"low"}],"references":[{"label":"Banister · ACS Chem Neurosci 2016","pmid":"27421060","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/27421060/"}]},"pharmacokinetics":null,"metabolism":null,"detection":null,"subjectiveEffects":{"profile":[{"key":"calm","label":"Apaisement","description":"Détente du corps et de l'esprit ; baisse du bruit mental sans somnolence marquée.","intensity":20},{"key":"focus","label":"Clarté","description":"Attention soutenue et pensée claire ; lucidité fonctionnelle, pas d'euphorie.","intensity":15},{"key":"sleep","label":"Sommeil","description":"Effet sédatif : aide à l'endormissement et à la continuité du sommeil profond.","intensity":60},{"key":"appetite","label":"Appétit","description":"Stimulation de la faim et de l'appréciation gustative (effet « munchies »).","intensity":45},{"key":"uplift","label":"High","description":"Euphorie et intensité sensorielle ; perception du temps et de l'espace modifiée.","intensity":99}],"doseRanges":null,"humanDataCharacterised":false},"indications":{"approvedMedicines":[]},"harmProfile":{"unstudiedBanner":true,"bannerTextFr":"Aucune dose humaine caractérisée : données animales / in vitro uniquement. Profil d'effet, marge de sécurité et toxicité aiguë non documentés en clinique humaine.","toxicologyFr":null},"legal":{"scheduleStatus":"controlled-named","scheduleLabel":"Stupéfiant : nommément listé","frScheduleStatus":null,"tiers":[{"jurisdiction":"international","jurisdictionLabel":"International","label":"1971 Schedule II","reference":"CND 62/8 (Mar 2019)","url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"eu","jurisdictionLabel":"Union européenne","label":"Décision Conseil (UE) 2018/1485","reference":null,"url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null},{"jurisdiction":"fr","jurisdictionLabel":"France","label":"Annexe IV : listé","reference":"Arrêté 31 mars 2017, NOR AFSP1710288A","url":null,"effectiveDate":null,"lastVerified":"2026-05-01","supersededBy":null}],"sourcesFr":"EUR-Lex, UNODC, CND, ANSM, IUPHAR/BPS, ChEBI, EUDA."},"references":[{"label":"Banister · ACS Chem Neurosci 2016","pmid":"27421060","doi":null,"url":"https://pubmed.ncbi.nlm.nih.gov/27421060/"}],"meta":{"slug":"5f-mdmb-pinaca","url":"https://phytogrammes.com/wiki/5f-mdmb-pinaca","lastVerified":"2026-05-01","dataUpdatedAt":"2026-05-01","confidence":"medium","dataCompletenessPct":90,"disclaimerFr":"Contenu éditorial informatif, sans valeur d'avis médical ni juridique. Sources primaires citées par fiche. Réservé aux adultes."}}